Sacha stevenson biography samples
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Bestsellers
Tuesdays with Morrie
- 20th Anniversary Edition
- By: Mitch Albom
- Narrated by: Mitch Albom
- Length: 3 hrs and 51 mins
- Unabridged
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Maybe it was a grandparent, or a teacher, or a colleague. Someone older, patient and wise, who understood you when you were ung and searching, helped you see the world as a more profound place, gave you sound advice to help you man your way through it....
- 4 out of 5 stars
Once you learn how to die, you learn how to live
- By AudioAddict on 04-17-16
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Experience on postmortem minimally invasive tissue sampling to ascertain the cause of death determination in South African children: A case for implementing as standard of care
Authors
- J du Toit South African Medical Research Council Vaccines and Infectious Diseases Analytics Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
- K Storath South African Medical Research Council Vaccines and Infectious Diseases Analytics Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
- I Dunn South African Medical Research Council Vaccines and Infectious Diseases Analytics Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
- P Makekeng South African Medical Research Council Vaccines and Infectious Diseases Analy
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Abstract
The biogenesis and maintenance of cell organelles such as mitochondria and chloroplasts require the import of many proteins from the cytosol, a process that is controlled by phosphorylation. In the case of chloroplasts, the import of hundreds of different proteins depends on translocons at the outer and inner chloroplast membrane (TOC and TIC, respectively) complexes. The essential protein TOC159 functions thereby as an import receptor. It has an N-terminal acidic (A-) domain that extends into the cytosol, controls receptor specificity, and is highly phosphorylated in vivo. However, kinases that phosphorylate the TOC159 A-domain to enable protein import have remained elusive. Here, using co-purification with TOC159 from Arabidopsis, we discovered a novel component of the chloroplast import machinery, the regulatory kinase at the outer chloroplast membrane 1 (KOC1). We found that KOC1 is an integral membrane protein facing the cytosol and stably associates with TOC. Mor