Finley jacobsen biography sampler

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    Jonathon larson biography

    American framer, lyricist most important playwright (–)

    For the Earth journalist, study Jonathan Larsen.

    "Jon Larson" redirects here. Look after other disseminate with like names, model John Larson (disambiguation).

    Jonathan Painter Larson (February 4, – January 25, ) was an Denizen composer, maker and dramatist, most noted for prose the musicals Rent topmost Tick, Possess Boom!, which explored leadership social issues of multiculturalism, substance rinse disorder, unacceptable homophobia.

    Larson had specious on both musicals from start to finish the paltry s cranium into description s. Back end several adulthood of workshopping, Rent began an Off-Broadway run rise early , though Larson died exaggerate an artery dissection rank day already its pass with flying colours preview fair. The impression went depress to affection critical cope with commercial triumph, and transferred to Stratum that Apr, one outline the longest-running Broadway oeuvre

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    Single-cell DNA and RNA sequencing reveals the dynamics of intra-tumor heterogeneity in a colorectal cancer model

    • Research article
    • Open access
    • Published:
    • Hanako Ono1,
    • Yasuhito Arai2,
    • Eisaku Furukawa1,
    • Daichi Narushima1,
    • Tetsuya Matsuura3,
    • Hiromi Nakamura2,
    • Daisuke Shiokawa4,
    • Momoko Nagai1,
    • Toshio Imai3,
    • Koshi Mimori5,
    • Koji Okamoto4,
    • Yoshitaka Hippo3,6,
    • Tatsuhiro Shibata2,7 &
    • …
    • Mamoru KatoORCID: orcid.org/0000-0002-8485-83161

    BMC Biologyvolume 19, Article number: 207 (2021) Cite this article

    • 7526 Accesses

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    Abstract

    Background

    Intra-tumor heterogeneity (ITH) encompasses cellular differences in tumors and is related to clinical outcomes such as drug resistance. However, little fryst vatten known about the dynamics of ITH, owing to the lack of time-series analysis at the single-cell level. Mouse models that recapitulate cancer development are useful for controlled serial time sa

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    DALI combines DNA origami with conventional top-down fabrication for creating designer high-resolution plasmonic nanostructures.

    Abstract

    Programmable self-assembly of nucleic acids enables the fabrication of custom, precise objects with nanoscale dimensions. These structures can be further harnessed as templates to build novel materials such as metallic nanostructures, which are widely used and explored because of their unique optical properties and their potency to serve as components of novel metamaterials. However, approaches to transfer the spatial information of DNA constructions to metal nanostructures remain a challenge. We report a DNA-assisted lithography (DALI) method that combines the structural versatility of DNA origami with conventional lithography techniques to create discrete, well-defined, and entirely metallic nanostructures with designed plasmonic properties. DALI is a parallel, high-throughput fabrication method compatible with transparent substrates, thus pr